Showing posts with label vitamins. Show all posts
Showing posts with label vitamins. Show all posts

How to Increase Appetite Naturally: 5 Best Ways

Although overeating is a major problem in this country, undereating is a problem for many individuals who want to gain strength and muscle mass. Often it’s not their intent to eat light, but they simply do not have an appetite. And without enough calories, they will not be able to train as hard as they can and then recover adequately. Here we describe how to increase appetite.

Of course, if you go on the Internet and consult Mr. Google, you can find many funky solutions – such as getting a prescription for the drug Periactin and smoking cannabis, or better yet, getting a prescription for cannabis. While it’s true that smoking cannabis does cause the “munchies", it does so at the cost of cutting down motivation and lowering testosterone for extended periods of time. And yes, the drug Periactin does increase appetite, but it can make you drowsy, therefore reducing your training drive – oh, and there are a few other possible side effects, including fever, seizures and hallucinations.

How to Increase Appetite Naturally: 5 Best Ways
Are there safer and more effective alternatives to improving your appetite, ones that don’t involve controlled substances? There certainly are. Here I present five for your consideration, along with several links to sites that have additional information on resolving this serious issue.

1. Verify your zinc status.


Zinc deficiency is one of the most common and most serious mineral deficiencies. Whenever I test my clients for the first time, I’ve found that roughly 98 percent are zinc deficient. It’s so common that it’s probably safe for any trainer to assume that all their clients are zinc deficient until they can prove otherwise. And this is not good.
Besides compromising your testosterone levels and increasing aromatization of your testosterone to estrogen, low levels of zinc are associated with poor appetite levels. One reason for this is that you need zinc to make HCl, the primary substance that regulates digestion of proteins. Another reason is that zinc affects how your food tastes, therefore affecting your appetite. A BioSignature practitioner can work with you in using the Zinc Tester to give you an idea of your zinc status.


To verify your zinc status most accurately, ask your physician to measure your red blood cell (RBC) zinc, NOT serum zinc levels. Strength and power athletes train most efficiently at RBC zinc levels of 1,400 to 1,500 ug/dL. By getting the proper amount of zinc, not only will you boost your appetite, your testosterone, immune system and tendon strength will soar. If you score low, take 2 Über Zinc twice a day for 12 weeks, and then remeasure your RBC zinc to adjust your zinc intake properly.

2. Use injectable forms of folic acid and B12.


Those two forms of B vitamins are critical in stimulating the appetite, and the most effective way to achieve optimal levels is through injection. Your physician can prescribe the injectable forms for you; 1 cc of each, twice a week, usually does the trick. Undiagnosed low stomach acid is linked to various neurological disorders such as dementia and Alzheimer’s because those ailments are linked to folic acid and B12 status (i.e. no stomach acid, no folic acid and B12 absorption). Which brings us to tip number three.

3. Restore your HCl levels.


Hydrochloric acid (HCl) is a stomach acid that helps to break down food into useable nutrients and kills pathogenic bacteria that enter the body through food. The increased acid levels in the stomach will improve the absorption of protein, calcium, vitamin B, magnesium, zinc, iron, and other basic nutrients. Having low levels of HCl decreases your appetite for protein.

4. Start the day with lime juice diluted in water.


This is an inexpensive trick that works well. Foods can be classified as being alkalizing or acidifying, as determined by what’s known as a pH scale. The pH scale is measured from 0 to 14, with 0 to 7 considered acidic and 7.1 to 14 considered alkaline. Adding lime juice to water creates a slightly acidic solution that will stimulate your HCl production. The paradoxical part is that the solution helps to alkalize you, which is anabolic in itself, as an alkaline state negates the catabolic effects of cortisol.

5. Salt your food properly.


Functional medicine tests show, over and over, that high-protein consumers are in fact sodium deficient. But it has to be the right kind of sodium. Salt your meat and fish dishes liberally.

In addition, the following can also contribute to a loss of appetite:

Medications

  • Some antibiotics affect the taste buds. They can also slow the movement of food through the intestines. This prolongs the feeling of fullness after a meal.
  • Chemotherapy drugs may affect the taste of certain foods or cause nausea or a loss of appetite.
  • Pain relievers and anti-arthritis medications can irritate the stomach. This can cause nausea and a distaste for food.
  • Some heart medications and diuretics can also dampen the desire to eat.
  • Never stop taking any medication without first talking to your doctor.

Poor nutrition

  • Overall nutrient deficiencies can take a toll on an otherwise healthy appetite.
  • Older people in particular may suffer from a low intake of zinc. A zinc deficiency can deaden taste buds.

Illness

  • You may feel less like eating if you have certain lung problems, congestive heart failure or cancer. Being in a lot of pain from arthritis can affect your appetite, too.
  • Depression and loneliness can rob some people of their desire to eat.


If you apply these tips, your lack of appetite will cease to hamper your gains. In the comments section below you can describe what has worked for you in the past to increase your appetite.

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Vitamins That Will Save Your Eyes

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Introduction


There has been a lot of interest in the role of nutrition and nutritional supplements, such as vitamin tablets, and their effect on vision. The main focus has been on how vitamins and minerals might affect age-related eye conditions such as age-related macular-degeneration (AMD) and cataracts. This page explores these issues and looks at the importance of good nutrition and how the eye can be affected by it.

The importance of good nutrition


Good nutrition is very important for both your general and eye health. Good nutrition helps our body to grow, repair wear and tear, protect against infection and to function properly. An eye condition called ‘xerophthalmia’, which is a common cause of childhood blindness in developing countries, is a good example of how nutrition and eye health go hand in hand. This condition is caused by a lack of vitamin A in a person’s diet and could be prevented by eating fresh vegetables, fat (animal and plant) and protein (eg meat, eggs, cheese, fish, poultry, milk, yoghurt, dairy products, nuts, seeds, pulses and grains).

Vitamins That Will Save Your Eyes

What might cause age-related eye disease?


There are many causes for the various different eye conditions.

Sometimes an eye condition can be related to another medical condition, and some are inherited. Much research is being carried out in various areas of eye health. Often there is no known cause for the development of an eye condition - these conditions are often known as ‘idiopathic’.

A few possible risk factors of eye disease are:

Age

Although it may sound obvious, age is the biggest risk factor in age-related eye disease. As we get older the changes in our body processes also affect our eyes.

Oxygen is essential for the human body, but it can also be harmful. Oxygen can produce “free-radicals” which damage cells or prevent them from regenerating as they used to. This cell regeneration process is affected as we get older due to free radicals and other factors.

Our bodies do have a natural protection against the effect of free radicals but under certain conditions this protection is not good enough.


Free radicals damage the retina, a light sensitive layer at the back of the eye. They also affect the lens, a clear tissue found behind the coloured part of the eye known as the iris. The lens helps to focus light onto the retina which then sends an image of what we are looking at to our brain. This is how we see. Mostly, these free radicals are neutralised by the body’s defences. Most vitamins and minerals can help the body and our eyes to combat the effects of free radicals. These vitamins and micronutrients are known as antioxidants and their role in maintaining eye health will be explored in this leaflet.

Smoking

Smoking causes harm to the tissues of the eye. Research has confirmed the direct, harmful effects of smoking on eyesight, particularly in the development of cataracts and age-related macular degeneration (AMD). We also know that smoking can make diabetes-related sight problems worse. Cigarette smoking increases free radicals which accelerate ageing and alters the body’s ability to absorb or extract necessary vitamins and minerals from food. Smoking reduces appetite which may result in a poor diet. Poor nutrition also has an adverse effect on eye health. Passive smoking, that is not smoking yourself but breathing in other people’s smoke, is almost as harmful as smoking yourself.

While cataracts are treatable and therefore do not lead to blindness, they remain a major cause of sight loss in the UK. Treatment options for AMD are limited and smokers do not only double their risk of developing AMD, they also tend to develop it earlier than non-smokers.

It has been shown that stopping smoking can reduce the risk of macular degeneration developing. Your GP can tell you about NHS stop smoking services in your area.

Diet

A balanced diet, with plenty of fresh fruits and vegetables is good for your eye health. Eating a diet low in saturated fats but rich in omega 3 fats and micronutrients derived from green leafy vegetables, fruit, fish and nuts may help prevent and slow down the progression of AMD and age-related cataracts.

Obesity

Obesity is increasingly being discussed as a risk factor for sight loss. Recent research suggests that obesity may put someone more at risk of developing an eye condition which can cause sight loss, including AMD, cataracts and retinal vein occlusion. In addition, obesity significantly increases the risk of developing diabetes and with it, diabetic retinopathy. Further research is now needed to gain better understanding of the links between obesity and these eye conditions.

Sunlight

It has been suggested that eyes can be damaged by continuous exposure to intense sunlight. Many studies show that prolonged periods of sunlight exposure are a risk factor for the development of AMD. The sun’s rays have been linked to the development of cataracts.

For this reason it is very important to reduce exposure of the eye to sunlight. Sunglasses that offer good protection from all angles, are recommended. These not only protect the eye from direct sunlight but also from scattered or reflected light that can enter the eye from above, the sides or below. Wearing a hat with a good brim can decrease eye exposure to light by 30-50 per cent. Sunglasses and hats are, therefore, also recommended for children.

Gender

There is a higher rate of AMD and cataracts among women, possibly because they tend to live longer than men. There also seems to be a hormonal influence and it is reported that Hormone Replacement Therapy (HRT) can reduce these risks.

Nutrition for the eye



Vitamins and the eye

In various studies and clinical trials antioxidant vitamins found in certain foods have been linked with eye health. They help to maintain healthy cells and tissues in the eye.

The main focus has been on the anti-oxidant vitamins A, C and E. These vitamins can be found in many different sources of fruit and vegetables such as oranges, kiwis, grapefruit, dried apricots, tomatoes, peppers, raw carrots, green leafy vegetables including kale and spinach, green peas, green beans and brussel sprouts. They can also be found in nuts, seeds, dairy products and eggs. These are only a few of the food types in which antioxidant vitamins can be found. The British Nutrition Foundation can provide you with further information on this. Their contact details are at the end of this leaflet.

Lutein and eye health

More recently it has been suggested that two types of antioxidants, known as ‘carotenoids’, called Lutein (pronounced Loo-teen) and Zeaxanthin (pronounced Zay-a-za-thin) may also help with eye health. Some studies have found that people who have a good diet rich in carotenoids, particularly lutein and zeaxanthin, have a lower risk of developing AMD. Lutein and Zeaxanthin can be found naturally in vegetables and fruit. For example, Lutein can be found in yellow peppers, mango, bilberries, and green leafy vegetables such as kale, spinach, chard and broccoli. Zeaxanthin can be found in orange sweet peppers, broccoli, corn, lettuce (not iceberg), spinach, tangerines, oranges and eggs. Many of these overlap with food types in which vitamins A, E and C are present.

Vitamins supplements and diet
Age-related macular degeneration (AMD)

A large research trial, called the ‘Age-Related Eye Disease Study’ (AREDS), showed that high quantities of the antioxidant vitamins A, C, E, beta-carotene and the minerals zinc as zinc oxide, and copper as cupric oxide, can help to slow down the progression of AMD. It would be very hard to obtain the large quantity of vitamins used in the trial from your diet. Therefore some people who have AMD may consider supplementation with vitamins and anti-oxidants. Such high dosages of vitamins and minerals might have possible side effects on the body.

For this reason it is very important to consult your doctor first before taking a supplement.

Eye health

Following the AREDS research trial there have been over 150 smaller scale studies looking at how vitamins and minerals, both from food and in a vitamin supplement, can help eye health in general, and in particular AMD and cataracts. A number of these studies have looked specifically at the carotenoids Lutein and Zeaxanthin which have been particularly associated with healthy eyes.

Some of these studies have shown how certain vitamin and mineral supplements can have a positive effect on eyes and sight. Others have shown there to be no or little benefit. For this reason various organisations are calling for further, larger scale research.

As a result of these studies there are now a number of different supplements for eye health on the market. There is still divided medical opinion on the use of supplements for both eye health and for preventing, or slowing down, the progression of AMD and cataracts in particular.

The general consensus of opinion is that with a good balanced diet that includes sufficient fresh fruits and vegetables there should be no need to use supplements.

However, research has shown that many people in the UK do not get enough vitamins and minerals from their diet. Some people might consider taking a supplement for their general and eye health when :
  • their diet does not include enough fresh fruit and vegetable
  • diet does not include enough vitamins and minerals
  • vitamins and minerals from food are not adequately absorbed by the body
  • it is hard to obtain or prepare fresh fruit and vegetables
  • they have been told to take a supplement by their doctor or nutritionist.

However, experts agree that taking supplements is not a substitute for a healthy diet



Conclusion


Evidence regarding the benefits of nutritional supplements against eye disease is conflicting and there is no real agreement among researchers on this subject at present. However, a consensus has been reached on the importance of a healthy, balanced diet full of fresh fruits and vegetables, particularly leafy green vegetables such as kale and spinach.

Key points to remember:


  • Eat a good, balanced diet with lots of fresh fruit and vegetables.
  • Discuss changing your diet or taking vitamin supplements with your GP.
  • Discuss your diet or taking a vitamin supplement with your GP if you believe that your diet may be inadequate.
  • The biggest avoidable risk is smoking.
  • Protect your eyes from sunlight. Use good quality sunglasses, ie those that have the ‘CE’ mark, which means they meet the European Union Quality Standards. Wearing a brimmed hat also offers very good protection.
  • Get your eyes tested at least every two years and more frequently if necessary.

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Was Interested In Ocular Nutrition?

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Several vitamins, minerals (green leafy vegetable ingredients) and herbs have used in an attempt to treat or prevent the development of cataract, glaucoma, macular degeneration and diabetic retinopathy. Although anecdotal evidence abounds, the lack of large scale controlled trials make definite recommendations difficult. This is not surprising since most of the aging eye diseases progress slowly and a multitude of factors (genetic and environmental) affect their development and progression, so that it becomes very difficult to isolate the influence of a specific vitamin or mineral on this process. On this page we discuss the nutrients that over time have been suggested to play a possible role.

In the absence of specific contraindications and side effects, most physicians seem it reasonable to use these nutrients as an adjunct to specific medical therapy - i.e. "can't hurt and might help" approach. Perhaps the most reasonable recommendation would be to increase the dietary intake of green leafy vegetables (for Carotenoids) and fruits & vegetables like carrots and cantaloupe which have reddish pigment (for beta-Carotene). Was Interested In Ocular Nutrtion?There is a risk however. Patients affected by these diseases are willing to grasp at any straw in desperation, because in advanced disease medical therapy seems to offer so little hope. This is especially true for macular degeneration and glaucoma. Therefore, despite claims of cure with expensive alternative treatments, refrain from unreasonable expectations is prudent.

There is concern about eating green leafy vegetables if you are on Warfarin (Coumadin), a blood thinner. Warfarin reduces the ability of blood to clot by blocking Vitamin K; however, large amounts of Vitamin K can overcome the effects of warfarin. Green leafy vegetables are high in vitamin K. According to the National Stroke Association, patients taking Warfarin do not need to avoid foods that are high in vitamin K-- rather, they should avoid against abruptly changing the amount of vitamin K-rich foods consumed since the changes in vitamin K intake can alter the effect of warfarin, making warfarin ineffective (too much vitamin K in the diet) or causing bleeding (too little vitamin K in the diet). If you eat a relatively constant amount of green vegetables then Warfarin levels would be unlikely to fluctuate.

Vitamin C, Vitamin E, beta-Carotene (pro-Vitamin A) and Carotenoids (Lutein & Zeaxanthin) are strong antioxidants i.e. they protect the eye against free radical damage. It seems reasonable to assume that strengthening of the eye defences by increasing the intake of these vitamins would be helpful in preventing the chronic AgingEye diseases. Recent well designed and controlled studies seem to support this assumption. Lycopene (a different type of carotenoid found in tomatoes) protects against prostate cancer and heart disease — therefore the protective effect of these vitamins is not just restricted to the eye.

Nutritional supplements and Macular Degeneration


The Age-Related Eye Disease Study (AREDS) was a major study sponsored by the National Eye Institute (NEI). In the study, scientists looked at the effects of zinc and antioxidants (vitamin C, vitamin E & beta carotene i.e. provitamin-A), on patients with cataracts and age-related macular degeneration (AMD). Lutein was not part of this study because during the planning stages in the early 1990s, lutein and zeaxanthin were not commercially available.

The study reported a beneficial effect of antioxidants + zinc in patients who have moderate to advanced macular degeneration (i.e. those who have extensive intermediate size drusen or at least 1 large drusen or geographic atrophy in 1 or both eyes, or visual acuity worse than 20/32 attributable to macular degeneration). The study showed that treatment with antioxidants + zinc reduced the risk of progression of moderate macular degeneration to advanced macular degeneration by 25%. (see graph). Vitamin supplements do not provide as much benefit to patients with minimal macular degeneration. These nutritional supplements do not prevent the development of macular degeneration, nor can one recover vision already lost to macular degeneration. In this study, nutritional supplements do not seem to prevent cataracts, or to keep them from getting worse over time, although other studies have shown such a beneficial affects. The dose of vitamin C used was about 5 times what the general population receives from diet alone. The dose of vitamin E was about 13 times the recommended daily allowance and the dose of zinc was about 5 times the recommended daily allowance. These levels of zinc and vitamins C and E generally can be obtained only by supplementation.

While most patients in the study experienced no serious side effects from the doses of zinc and antioxidants used, a few taking zinc alone had urinary tract problems that required hospitalization. Some patients taking large doses of antioxidants experienced some yellowing of the skin. The long-term effects of taking large doses of these supplements are still unknown.

If you have intermediate (or advanced macular degeneration in one eye only), talk to your physician about taking nutritional supplements. Your doctor can help you determine if they may be beneficial-and safe-for you, and what types and doses of supplements to take. The doses used in the study were: Vitamin C 500 mg, Vitamin E 400 IU, Beta-carotene 15 mg, Zinc 80 mg, as zinc oxide, Copper 2 mg, as cupric oxide (copper should be taken with zinc, because high-dose zinc is associated with copper deficiency). Ophthalmologists and others prescribing the AREDS formula to their patients should recognize that this is not a multivitamin; if the patient needs additional vitamins (e.g., B vitamins or vitamin D), other products must be used. To know more about the NEI macular degeneration study read or print the NIH News Release about this study or view the video.

It is very important to talk with your physician before taking large-dose supplements, and to follow the dosage recommendations carefully. Megadoses of vitamins have well defined health risks. Some supplements may interfere with each other or other medications. Smokers and ex-smokers probably should not take beta-carotene, as studies have shown a link between beta-carotene use and lung cancer among smokers.An estimated 8 million persons at least 55 years old in the United States have intermediate or advanced macular degeneration. Of these 8 million, 1.3 million would develop advanced macular degeneration if no treatment were given to reduce their risk. If all of these people at risk received supplements such as those used in AREDS, more than 300 000 of them would avoid advanced macular degeneration and any associated vision loss during the next 5 years.


Aging Eye Times recommendation:


We urge clinicians to be cautious when advising patients with macular degeneration regarding the benefits of ocular vitamin/mineral supplements. These nutrients are not a cure for macular degeneration, nor will they restore vision already lost from the disease, but they may help some people at high risk for developing advanced macular degeneration keep their vision. Based on data from AREDS, persons older than 55 years should have dilated eye examinations to determine their risk of developing advanced macular degeneration. Patients who have moderately advanced macular degeneration and are not current or past smokers, should consider taking a supplement of antioxidants plus zinc. In patients who have early macular degeneration, it seems reasonable to defer consideration of supplementation. If patients with early macular degeneration choose to take the supplements, then they must understand that their decision to do so is not supported by a demonstrated benefit and any presumed beneficial effect on preventing the progression of macular degeneration is mere speculation. Approximately 80% of Americans older than age 70 will fall in the low-risk group of early or no macular degeneration.
All patients should be encouraged to eat a balanced diet rich in fruits and vegetables, and in particular they should be informed by they clinician on the dietary sources rich in these carotenoids. We further recommend patients to wear UV protective lenses and a hat or cap when outdoors and suggest they see their primary care physician to treat any hypertension, hypercholesterolemia or potentially compromising vascular disease.


Lutein & Zeaxanthin role in Eye Disease Prevention


The macula is yellow in color due to the presence of pigment, which is composed of two dietary carotenoids, lutein and zeaxanthin. By absorbing blue-light, lutein and zeaxanthin pigments protect the photoreceptor cells of the retina from light damage. In addition, lutein & zeaxanthin are antioxidants, able to prevent free-radical damage to the macula. If the macula has more lutein and zeaxanthin, the protection against light damage is also greater. The macular pigment can be increased in by either increasing the intake of foods that are rich in lutein and zeaxanthin, such as dark-green leafy vegetable, or by supplementation with lutein and zeaxanthin.

While the assumption that increasing the intake of lutein or zeaxanthin may protect against the development of age-related macular degeneration has a strong scientific basis, a causative relationship has yet to be unequivocally demonstrated in rigorous controlled studies. Given the evidence to date, the advice to increase the intake of lutein & zeaxanthin seems reasonable.

A number of studies intended to examine trends in a population suggest a link between lutein and decreased risk of eye disease:



  • In 1994, a National Eye Institute (NEI)-supported study indicated that consumption of foods rich in carotenoids — particularly green, leafy vegetables such as collard greens, kale and spinach — was associated with a reduced risk of developing macular degeneration.

  • In 1999, data from the Nurses Health Study showed a reduced likelihood of cataract surgery with increasing intakes of lutein and another carotenoid --zeaxanthin.

  • In 1999, the Health Professionals Follow-up Study found a trend toward a lower risk of cataract extraction with higher intakes of lutein and zeaxanthin.

  • In 1999, a follow-up to an NEI-supported population-based study -- called the Beaver Dam Study -- concluded that people with diets higher in lutein and zeaxanthin had a lower risk of developing cataract.

  • In 2001, data from the Third National Health and Nutrition Examination Survey reported that higher intakes of lutein and zeaxanthin among people ages 40-59 may be associated with a reduced risk of advanced macular degeneration.

Lutein & Zeaxanthin were not part of this AREDS (macular degeneration study) because during the planning stages in the early 1990s, lutein and zeaxanthin were not commercially available. Therefore, the recently released results of the macular degeneration study could not advice on lutein.

It seems reasonable to conclude that the trends and available evidence to date supports a beneficial affect for lutein in preventing eye diseases.


Nutritional supplements and Cataracts


Compared with nonusers, the risk for cataract is 60% lower among persons who use multivitamins or any supplement containing vitamin C or E for more than 10 years. Use of vitamins for shorter duration is not associated with reduced risk for cataract (Arch Ophthalmol 2000;118:1556-63). Vitamin C reduces the risk of cortical cataracts in women aged 60 years or less & carotenoids reduce the risk of posterior subcapsular cataract (PSC) in women who have never smoked (Am J Clin Nutr 2002;75:540-9). A recent research report also suggests that lutein and zeaxanthin (the only carotenoids found in the lens) may retard aging of the lens (Arch Ophthalmol 2002;120:1732-7). Higher intakes of protein, vitamin A, niacin, thiamin, and riboflavin (i.e. vitamin B-complex) are associated with reduced prevalence of nuclear cataract (Ophthalmology 2000;107:450-6).

The combined weight of the evidence suggests that long-term use of vitamin supplements (containing vitamin-C, E and carotenoids) may be of value in delaying cataract development.

Years ago, Nobel laureate Linus Pauling advocated megadoses (1,000 to 2,000 mg per day) of Vitamin C to fend off colds and prevent cancer. Studies have found no benefit from such massive doses of vitamin C, but a different line of research suggests that just a little extra might be a good thing for women's eyes. Any protective effect of vitamin C probably occurs well above the Recommended Dietary Allowance (RDA) of 75 mg/day for women, about the amount in an orange (Women who smoke need more vitamin C 110 mg/day).

Research by the Nutrition and Vision Project (NVP), a cooperative effort of Harvard and Tufts University scientists, has found that women who consume higher-than-recommended doses of vitamin C may lower their risk for more than one type of cataract (Harv Womens Health Watch 2002;9:1). Boosting the vitamin C intake from both food and supplements to around 500 mg/day is probably a good idea, however discuss it with your doctor, especially if you have an increased risk for kidney stones.


Herbs and AgingEye Diseases


The use of herbal supplements in the US has become increasingly popular in recent years. In a survey conducted in 1999, about 49% of adult Americans were estimated to have used herbal products during the previous year (Journal of Clinical Pharmacy & Therapeutics 2002:27;391-401). Contributing to their increased use is the perception that herbs are safer, gentler and represent a more 'natural' way of curing disease than conventional drugs, which are viewed as chemicals.

These medications fall into the category of alternative/complementary medicines and, as such, are not regulated by the Food and Drug Administration (FDA) with the same scrutiny as conventional drugs. There is no pre-marketing review and post-marketing surveillance requirements for herbal supplements in the US. Their regulation by the FDA is restricted as a result of the Dietary Supplement Health and Education Act (DSHEA) passed by US Congress in 1994. These products are freely available to consumers as over-the-counter (OTC) items. The FDA has now established standards to ensure that dietary supplements and dietary ingredients are not adulterated with contaminants or impurities, and are labeled to accurately to reflect the ingredients in the product (News Release). There is still no requirement to show that dietary supplements are safe or effective.

As the use of herbal supplements in the US continues to grow under the prevailing scenario, some concerns have become apparent regarding the safety of these products. Of particular safety concern is potential interactions of these products with conventional drugs. It has been documented that as many as 31% of the patients who use herbal supplements do so in conjunction with prescribed drugs and about 70% of these patients do not regularly report the use of these products to their health care providers (Journal of Clinical Pharmacy & Therapeutics 2002:27;391-401). Of most concern is the bleeding tendency when herbs like Gingko are taken along with aspirin or other blood thinner.



Bilberry (Vaccinium myrtillus)


Bilberry has a long history of use for various eye conditions. The active components, flavonoid anthocyanosides, are potent antioxidants with a particular affinity for the eye and vascular tissues. Interest in bilberry was first aroused during World War II when British Royal Air Force pilots reported improved night visual acuity on bombing raids after consuming bilberries. Subsequent claims have been made that the administration of bilberry extracts results in improved night visual acuity, quicker adjustment to darkness and faster restoration of visual acuity after exposure to glare. In a report of 50 patients with age-related cataracts, a combination of bilberry and vitamin E delayed the progression of cataracts (Head K. Altern Med Rev 2001;6:141-166).

Bilberry has been used in the treatment of glaucoma as well.


Ginkgo Biloba


Ginkgo biloba extract is freely available and popular. An extract of Ginkgo leaves is commonly used for conditions associated with cerebral and peripheral ischaemia (e.g. dementia, impotency, claudication). Gingko has several biological actions which combine to make it a potentially useful agent in the treatment of glaucoma: improvement of central and peripheral blood flow, reduction of vasospasm, reduction of serum viscosity, antioxidant activity, platelet activating factor inhibitory activity, inhibition of apoptosis, and inhibition of excitotoxicity. The effect of Ginkgo biloba extract as a potential antiglaucoma therapy is undergoing scrutiny.

Bleeding may occur inside the eye in patients taking Gingko (N Engl J Med 1997 10;336:1108). One of its components, ginkgolide B, is a potent inhibitor of platelet-activating factor, which is essential for the induction of arachidonate-independent platelet aggregation. Bledding complications in the brain have also been reported.

A recent research article suggests that Ginkgo biloba extract (40 mg, orally, administered three times daily for 4 weeks) improves preexisting visual field damage in some patients with Normal Tension Glaucoma (Ophthalmology 2003;110:359-362). Visual field improvement theoretically could result from improved retinal ganglion cell function or improved cognitive abilities. Either of these effects could occur secondary to improved blood flow to the eye, the brain, or both to a neuroprotective effect of Gingko Biloba. Further studies are needed to determine by what mechanisms Gingko may benefit patients with glaucoma.


Coleus Forskohlii


The triterpene forskolin from the plant Coleus forskohlii stimulates the enzyme adenylate cyclase. Adenylate cyclase then stimulates the ciliary epithelium to produce cyclic adenosine monophosphate (cAMP), which in turn decreases eye pressure by decreasing aqueous humor inflow.

Results of studies using topical forskolin applications to decrease eye pressure have been mixed. To date, human studies on forskolin's effect on eye pressure have been limited to healthy volunteers. Several studies have found it effective at lowering eye pressure and decreasing aqueous outflow in healthy volunteers.


Salvia Miltiorrhiza


Salvia miltiorrhiza is a commonly used botanical in Chinese medicine. Injected intravenously, this botanical appears to improve microcirculation of the retinal ganglion cells.

In a human study, 121 patients with mid- or late-stage glaucoma with medication-controlled eye pressure received daily intramuscular injections of a 2 g/mL solution of Salvia miltiorrhiza alone or in combination with other Chinese herbs (four different groups). The results suggest a possible benefit from this herbal treatment. Double-blind evaluations of oral administration of Salvia seem warranted.


Wine and Macular Degeneration


Researchers reported in Journal of the American Geriatrics Society that people who drink wine in moderation may be less likely to develop age-related macular degeneration (AMD). This finding was based on an analysis of data collected between 1971 and 1975 for the National Health Nutrition and Examination Survey (NHANES-1) from 3,072 adults 45 to 74 years of age with eye-related changes that indicated AMD.
The National Eye Institute (NEI) believes that it would be premature to make any recommendations based on this single study. While this is an interesting finding that bears further investigation, the authors warn that the study should not be used to "draw inferences about a cause and effect relationship." It also should be noted that later studies have found no such relationship between AMD and wine drinking, and that the findings reported are of borderline significance.

The NEI agreed with the author's concerns about the reliability of the data indicating the amount of alcohol consumed, as these data are often subject to recall bias. In addition, the study did not completely take into account possible confounding factors, especially smoking. Many studies show that smoking is a risk factor for AMD. Since there is generally more smoking among alcohol users, smoking status should be taken into account in the analyses. NEI questioned, too, the reliability of the diagnosis of AMD in those surveyed. The methods used now to diagnose AMD in large studies have been improved and are quite different than those used in the early 1970's.


Related Topics:

How To Maintain And Improve Vision

Everything About Bilberry Foods

Improve Your Retina and Macula Health with Foods and Vitamins

Foods That Help to Improve Eyesight

100 Foods That Won't Kill You Right Now

Fruit Helps Prevent Eye Disease


[Source]
Read More...

How Spinach Helps To Improve Eyesight

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Calorie for calorie, leafy green vegetables like spinach with its delicate texture and jade green color provide more nutrients than any other food. Although spinach is available throughout the year, its season runs from March through May and from September through October when it is the freshest, has the best flavor and is most readily available.

How Spinach Helps To Improve EyesightThis chart below graphically details the %DV that a serving of Spinach provides for each of the nutrients of which it is a good, very good, or excellent source according to our Food Rating System. Additional information about the amount of these nutrients provided by Spinach can be found in the Food Rating System Chart. A link that takes you to the In-Depth Nutritional Profile for Spinach, featuring information over 80 nutrients, can be found under the Food Rating System Chart.

Nutrients in Spinach, Boiled. - Food Chart

Health Benefits

We all know that Popeye made himself super strong by eating spinach, but you may be surprised to learn that he may also have been protecting himself against osteoporosis, heart disease, colon cancer, arthritis, and other diseases at the same time.

Phytonutrient Flavonoids for Optimal Health

Researchers have identified at least 13 different flavonoid compounds in spinach that function as antioxidants and as anti-cancer agents.
(Many of these substances fall into a technical category of flavonoids known as methylenedioxyflavonol glucuronides.) The anticancer properties of these spinach flavonoids have been sufficiently impressive to prompt researchers to create specialized spinach extracts that could be used in controlled studies. These spinach extracts have been shown to slow down cell division in stomach cancer cells (gastric adenocarcinomas), and in studies on laboratory animals, to reduce skin cancers (skin papillomas). A study on adult women living in New England in the late 1980s also showed intake of spinach to be inversely related to incidence of breast cancer.

Spinach Carotenoid Combats Prostate Cancer

A carotenoid found in spinach and other green leafy vegetables fights human prostate cancer two different ways, according to research published in the the Journal of Nutrition. The carotenoid, called neoxanthin, not only induces prostate cancer cells to self-destruct, but is converted in the intestines into additional compounds, called neochromes, which put prostate cancer cells into a state of stasis, thus preventing their replication.

Spinach Flavonoid Combats Ovarian Cancer

Research calculating flavonoid intake in 66,940 women enrolled in the Nurses Health Study between 1984 and 2002 revealed that women whose diets provided the most kaempferol had a 40% reduction in risk of ovarian cancer, compared to women eating the least kaempferol-rich foods. In addition to spinach, foods richest in kaempferol include tea (nonherbal), onions, curly kale, leeks, broccoli, and blueberries.

A significant 34% reduction in ovarian cancer risk was also seen in women with the highest intake of the flavone luteolin (found in citrus).

Helping You Bone Up

The vitamin K provided by spinach-almost 200% of the Daily Value in one cup of fresh spinach leaves and over 1000% of the Daily Value in one cup of boiled spinach (which contains about 6 times as much spinach)-is important for maintaining bone health. Vitamin K1 activates osteocalcin, the major non-collagen protein in bone. Osteocalcin anchors calcium molecules inside of the bone. Therefore, without enough vitamin K1, osteocalcin levels are inadequate, and bone mineralization is impaired. Spinach is also an excellent source of other bone-building nutrients including calcium and magnesium.

Cardiovascular Protection from Spinach

For atherosclerosis and diabetic heart disease, few foods compare to spinach in their number of helpful nutrients. Spinach is an excellent source of vitamin C and vitamin A, the latter notably through its concentration of beta-carotene. These two nutrients are important antioxidants that work to reduce the amounts of free radicals in the body; vitamin C works as a water-soluble antioxidant and beta-carotene as a fat-soluble one. This water-and-fat-soluble antioxidant team helps to prevent cholesterol from becoming oxidized. Oxidized cholesterol is able to stick to and build up in blood vessel walls, where it can cause blocked arteries, heart attack or stroke. Getting plenty of vitamin C and beta-carotene can help prevent these complications, and a cup of boiled spinach can provide you with 294.8% of the daily value (DV) for vitamin A along with 29.4% of the DV for vitamin C.

Spinach is also an excellent source of folate. Folate is needed by the body to help convert a potentially dangerous chemical called homocysteine that can lead to heart attack or stroke if levels get too high, into other benign molecules. In addition, spinach is an excellent source of magnesium, a mineral that can help to lower high blood pressure and protect against heart disease as well. A cup of boiled spinach contains 65.6% of the daily value for folate and 39.1% of the daily value for magnesium.

In addition to its hefty supply of cardioprotective vitamins and minerals, a study published in the Journal of Agriculture and Food Chemistry has revealed that spinach Rubisco contains four peptides (protein components) that inhibit angiotensin I-converting enzyme-the same enzyme blocked by ACE inhibitor drugs, which are used to lower blood pressure. When given to laboratory animals bred to be hypertensive, spinach produced a blood pressure lowering effect within two to four hours. How much spinach did the animals have to eat to get this beneficial effect? Just 20 to 30 mg of these powerful spinach peptides for each kilogram (2.2 pounds) of their body weight. In human terms, what this suggests is that an entrée-sized spinach salad for lunch or a serving of steamed spinach as part of the evening meal may have a salutary effect on blood pressure two to four hours later.

Promotes Gastrointestinal Health

The vitamin C and beta-carotene in spinach help to protect the colon cells from the damaging effects of free radicals. And the folate in spinach helps to prevent DNA damage and mutations in colon cells, even when they are exposed to cancer-causing chemicals. Studies show that people who eat foods high in vitamin C, beta-carotene, and/or folate are at a much lower risk of getting colon cancer than those who don't.

Anti-Inflammatory Nutrients

The nutrients in spinach can also help with conditions in which inflammation plays a role. For example, asthma, osteoarthritis, and rheumatoid arthritis are all conditions that involve inflammation. Since beta-carotene and vitamin C have anti-inflammatory properties, they can be helpful for reducing symptoms in some patients. In addition, the magnesium and riboflavin in spinach, two nutrients of which it is an excellent source, may help to reduce the frequency of migraine attacks in people who suffer from them.

A Smarter Brain with Spinach

In animal studies, researchers have found that spinach may help protect the brain from oxidative stress and may reduce the effects of age-related related declines in brain function. Researchers found that feeding aging laboratory animals spinach-rich diets significantly improved both their learning capacity and motor skills. Read more about brain benefits of spinach.

Vitamin E-rich Leafy Greens Slow Loss of Mental Function

Mental performance normally declines with age, but the results of Chicago Health and Aging Project (CHAP) suggest that eating just 3 servings of green leafy, yellow and cruciferous vegetables each day could slow this decline by 40%, suggests a study in the journal Neurology (Morris MC, Evans DA, et al.) Compared to people who consumed less than one serving of vegetables a day, people who ate at least 2.8 servings of vegetables a day saw their rate of cognitive decline slow by roughly 40%. This decrease is equivalent to about five years of younger age, said lead author Martha Clare Morris, ScD, with Rush University Medical Center in Chicago.

The prospective cohort study, funded by the National Institute of Aging, used dietary data from 3,718 participants (62% female, 60% African American, average age 74). Mental function was assessed with four different tests: the East Boston Tests of immediate memory and delayed recall, the Mini-Mental State Examination, and the Symbol Digit Modalities Test, taken at the start of the study and then again after 3 and 6 years.

After adjusting the results for potential confounders such as age, sex, race, education, and cardiovascular risk factors, the researchers found that consuming an average of 2.8 vegetable servings each day was associated with a 40% decrease in cognitive decline, compared to those who ate an average of less than one (0.9) serving a day. Of the different types of vegetables, green leafy vegetables had the strongest association, said Dr. Morris.

Surprisingly, no relationship was found between fruit consumption and cognitive decline.

Morris hypothesizes that this may be due to the fact that vegetables, but not fruits, contain high amounts of vitamin E, which helps lower the risk of cognitive decline. Also, vegetables, but not fruits, are typically consumed with a little fat, such as olive oil or salad dressing, which increases the body's ability to absorb vitamin E.

The Rush University researchers plan further research to understand why fruit appears to have little effect and to explore the effects of citrus fruit, specifically, on cognitive decline. Bottomline: If you remember to enjoy at least 3 servings of leafy greens each day, you are much more likely to remember other things as well!

Better Eyesight from Spinach

Lutein, a carotenoid protective against eye diseases such as age-related macular degeneration and cataract, is found in green vegetables, especially spinach, as well as kale and broccoli. But egg yolks, although they contain significantly less lutein than spinach, are a much more bioavailable source whose consumption increases lutein concentrations in the blood many-fold higher than spinach,shows a human study published in the Journal of Nutrition.

Although the mechanism by which egg yolk increases lutein bioavailability is not yet known, it is likely due to the fats (cholesterol and choline) found in egg yolk since lutein, like other carotenoids, is fat-soluble and cannot be absorbed unless fat is also present. To maximally boost your lutein absorption from spinach, we suggest enjoying this vegetable, whether steamed, sautéed or fresh in spinach salad, with a little olive oil and/or a topping of chopped hard-boiled egg to provide your body with some fats to help enhance the bioavailability of this fat-soluble phytonutrient.

Iron for Energy

Cooked spinach is an excellent source of iron, a mineral that it particularly important for menstruating women, who are more at risk for iron deficiency. Boosting iron stores with spinach is a good idea, especially because, in comparison to red meat, a well-known source of iron, spinach provides iron for a lot less calories and is totally fat-free. Iron is an integral component of hemoglobin, which transports oxygen from the lungs to all body cells, and is also part of key enzyme systems for energy production and metabolism. And, if you're pregnant or lactating, your needs for iron increase. Growing children and adolescents also have increased needs for iron. In one cup of boiled spinach, you'll be provided with 35.7% of the daily value for iron.

So while spinach probably won't make you super strong the minute you eat it, as it did for Popeye, it will promote your health and vitality in many other ways. It seems like Popeye was pretty smart after all.

Description

Spinach belongs to the same family (Chenopodiaceae) as chard and beets. It shares a similar taste profile with these two other vegetables-it has the bitterness of beet greens and the slightly salty flavor of chard.

Popeye popularized spinach, but it's too bad he ate it out of a can. Fresh spinach retains the delicacy of texture and jade green color that is lost when spinach is processed. Raw spinach has a mild, slightly sweet taste that can be refreshing in salads, while its flavor becomes more acidic and robust when it is cooked.

There are three different types of spinach generally available. Savoy has crisp, creased curly leaves that have a springy texture. Smooth-leaf has flat, unwrinkled, spade-shaped leaves, while semi-savoy is similar in texture to savoy but is not as crinkled in appearance. Baby spinach is great for use in salads as it has a sweeter taste, probably owing to its reduced concentration of oxalic acid. Spinacia oleracea is the scientific name of this leafy vegetable.

History

Spinach is thought to have originated in ancient Persia (Iran). Spinach made its way to China in the 7th century when the king of Nepal sent it as a gift to this country. Spinach has a much more recent history in Europe than many other vegetables. It was only brought to that continent in the 11th century, when the Moors introduced it into Spain. In fact, for a while, spinach was known as "the Spanish vegetable" in England.

Spinach was the favorite vegetable of Catherine de Medici, a historical figure in the 16th century. When she left her home of Florence, Italy, to marry the king of France, she brought along her own cooks, who could prepare spinach the ways that she especially liked. Since this time, dishes prepared on a bed of spinach are referred to as "a la Florentine."

Spinach grows well in temperate climates. Today, the United States and the Netherlands are among the largest commercial producers of spinach.

How to Select and Store

Choose spinach that has vibrant deep green leaves and stems with no signs of yellowing. The leaves should look fresh and tender, and not be wilted or bruised. Avoid those that have a slimy coating as this is an indication of decay.

Store fresh spinach loosely packed in a plastic bag in the refrigerator crisper where it will keep fresh for about five days. Do not wash it before storing as the moisture will cause it to spoil. Avoid storing cooked spinach as it will not keep very well.


Tips for Preparing Spinach:

Spinach, whether bunched or prepackaged, should be washed very well since the leaves and stems tend to collect sand and soil. Before washing, trim off the roots and separate the leaves. Place the spinach in a large bowl of tepid water and swish the leaves around with your hands as this will allow any dirt to become dislodged. Remove the leaves from the water, empty the bowl, refill with clean water and repeat this process until no dirt remains in the water (usually two to three times will do the trick). Cut away any overly thick stems to ensure for more even cooking. If you are going to use the spinach in a salad, you can dry it in either a salad spinner or by shaking it in a colander. If you are going to cook it, you do not need to worry about drying it well as the remaining water will serve to help it cook. Spinach is one of the few vegetables we suggest quick boiling (for one minute). That's because boiling will help to reduce the amount of oxalic acids found in spinach, resulting in a sweeter taste.

A Few Quick Serving Ideas:

  • Add layers of steamed spinach to your next lasagna recipe.
  • Toss steamed spinach with pressed garlic, fresh lemon juice and olive oil. Sprinkle with a little Parmesan cheese.
  • Pine nuts are a great addition to cooked spinach.
  • Spinach salads are a classic easy and delicious meal or side dish.

Allergic Reactions to Spinach

Although allergic reactions can occur to virtually any food, research studies on food allergy consistently report more problems with some foods than with others. It turns out that spinach is one of the foods most commonly associated with allergic reactions. Other foods commonly associated with allergic reactions include: cow's milk, wheat, soy, shrimp, oranges, eggs, chicken, strawberries, tomato, peanuts, pork, corn and beef. These foods do not need to be eaten in their pure, isolated form in order to trigger an adverse reaction. For example, yogurt made from cow's milk is also a common allergenic food, even though the cow's milk has been processed and fermented in order to make the yogurt. Ice cream made from cow's milk would be an equally good example.

Some of the most common symptoms for food allergies include eczema, hives, skin rash, headache, runny nose, itchy eyes, wheezing, gastrointestinal disturbances, depression, hyperactivity and insomnia. Individuals who suspect food allergy to be an underlying factor in their health problems may want to avoid commonly allergenic foods.

Spinach and Pesticide Residues

Virtually all municipal drinking water in the United States contains pesticide residues, and with the exception of organic foods, so do the majority of foods in the U.S. food supply. Even though pesticides are present in food at very small trace levels, their negative impact on health is well documented. The liver's ability to process other toxins, the cells' ability to produce energy, and the nerves' ability to send messages can all be compromised by pesticide exposure. According to the Environmental Working Group's 2006 report "Shopper's Guide to Pesticides in Produce," spinach is among the 12 foods on which pesticide residues have been most frequently found. Therefore, individuals wanting to avoid pesticide-associated health risks may want to avoid consumption of spinach unless it is grown organically.

Spinach and Oxalates

Spinach is among a small number of foods that contain measurable amounts of oxalates, naturally-occurring substances found in plants, animals, and human beings. When oxalates become too concentrated in body fluids, they can crystallize and cause health problems. For this reason, individuals with already existing and untreated kidney or gallbladder problems may want to avoid eating spinach. Laboratory studies have shown that oxalates may also interfere with absorption of calcium from the body. Yet, in every peer-reviewed research study we've seen, the ability of oxalates to lower calcium absorption is relatively small and definitely does not outweigh the ability of oxalate-containing foods to contribute calcium to the meal plan. If your digestive tract is healthy, and you do a good job of chewing and relaxing while you enjoy your meals, you will get significant benefits - including absorption of calcium - from calcium-rich foods plant foods that also contain oxalic acid. Ordinarily, a healthcare practitioner would not discourage a person focused on ensuring that they are meeting their calcium requirements from eating these nutrient-rich foods because of their oxalate content.

Spinach and Goitrogens

Spinach contains goitrogens, naturally-occurring substances in certain foods that can interfere with the functioning of the thyroid gland. Individuals with already existing and untreated thyroid problems may want to avoid spinach for this reason. Cooking may help to inactivate the goitrogenic compounds found in food. However, it is not clear from the research exactly what percent of goitrogenic compounds get inactivated by cooking, or exactly how much risk is involved with the consumption of spinach by individuals with pre-existing and untreated thyroid problems.

Spinach and Purines

Spinach contain naturally-occurring substances called purines. Purines are commonly found in plants, animals, and humans. In some individuals who are susceptible to purine-related problems, excessive intake of these substances can cause health problems. Since purines can be broken down to form uric acid, excess accumulation of purines in the body can lead to excess accumulation of uric acid. The health condition called "gout" and the formation of kidney stones from uric acid are two examples of uric acid-related problems that can be related to excessive intake of purine-containing foods. For this reason, individuals with kidney problems or gout may want to limit or avoid intake of purine-containing foods such as spinach.

Nutritional Profile

Spinach is an excellent source of vitamin K, vitamin A, manganese, folate, magnesium, iron, vitamin C, vitamin B2, calcium, potassium, and vitamin B6. It is a very good source of dietary fiber, copper, protein, phosphorous, zinc and vitamin E. In addition, it is a good source of omega-3 fatty acids, niacin and selenium.

In addition to the nutrients highlighted in our ratings chart, an in-depth nutritional profile for Spinach is also available. This profile includes information on a full array of nutrients, including carbohydrates, sugar, soluble and insoluble fiber, sodium, vitamins, minerals, fatty acids, amino acids and more. For an in-depth nutritional profile click here: Spinach.

Introduction to Food Rating System Chart

The following chart shows the nutrients for which this food is either an excellent, very good or good source. Next to the nutrient name you will find the following information: the amount of the nutrient that is included in the noted serving of this food; the %Daily Value (DV) that that amount represents; the nutrient density rating; and the food's World's Healthiest Foods Rating. Underneath the chart is a table that summarizes how the ratings were devised.

Content of Nutrients in the Spinach
Spinach, boiled
1.00 cup
180.00 grams
41.40 calories
NutrientAmountDV(%)Nutrient DensityWorld's Healthiest Foods Rating
vitamin K888.50 mcg1110.6482.9excellent
vitamin A14742.00 IU294.8128.2excellent
manganese1.68 mg84.036.5excellent
folate262.44 mcg65.628.5excellent
magnesium156.60 mg39.117.0excellent
iron6.43 mg35.715.5excellent
vitamin C17.64 mg29.412.8excellent
vitamin B2 (riboflavin)0.42 mg24.710.7excellent
calcium244.80 mg24.510.6excellent
potassium838.80 mg24.010.4excellent
vitamin B6 (pyridoxine)0.44 mg22.09.6excellent
tryptophan0.07 g21.99.5excellent
dietary fiber4.32 g17.37.5very good
copper0.31 mg15.56.7very good
vitamin B1 (thiamin)0.17 mg11.34.9very good
protein5.35 g10.74.7very good
phosphorus100.80 mg10.14.4very good
zinc1.37 mg9.14.0very good
vitamin E1.72 mg8.63.7very good
omega 3 fatty acids0.15 g6.02.6good
vitamin B3 (niacin)0.88 mg4.41.9good
selenium2.70 mcg3.91.7good


World's Healthiest
Foods Rating Rule
World's Healthiest Foods RatingRule
excellentDV>=75%ORDensity>=7.6ANDDV>=10%
very goodDV>=50%ORDensity>=3.4ANDDV>=5%
goodDV>=25%ORDensity>=1.5ANDDV>=2.5%



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Improve Your Retina and Macula Health with Foods and Vitamins

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Experts disagree on which nutrients can prevent eye disease or reduce vision loss, and there are many studies being conducted to help us learn more about the relationship between vitamins, minerals and antioxidants and eye health. They do agree, though, that the same things that are good for your body are good for your eyes: a healthy diet rich in fruits, vegetables and whole grains, drinking at least six glasses of water a day, regular exercise, and avoidance of cigarette smoke.

Much of the research that has already been conducted points to the benefits of vitamins and antioxidants, specifically beta carotene, vitamin E, vitamin C, zinc, selenium, copper, manganese and lutein. Improve Your Retina and Macula Health with Foods and VitaminsThe National Eye Institute's recent Age-Related Eye Disease Study found that about one-fifth of patients with advanced age-related macular degeneration (AMD) enjoyed a decreased risk of vision loss after taking high levels of zinc and antioxidants. The study did not find a correlation between these nutrients and the prevention or amelioration of cataracts, but others are more optimistic and recommend multivitamins as preventative measures for cataracts, dry eye and glaucoma.

Lutein is found in the macula, but it is not produced by the body. It can be found naturally in high concentrations in dark green and leafy vegetables, including spinach, collard and mustard greens, chicory, escarole, kale, lettuce, Swiss chard and turnip greens. Eating five or more servings per week (at least ½-cup per serving, cooked or raw) of these vegetables may reduce the risk or slow the progression of AMD. Patients taking the anticoagulant medication Coumadin should consult their doctors before increasing the amount of leafy greens they eat.
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The Mystery of Vitamin B12 Finally Solved

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The Mystery of Vitamin B12 Finally Solved
You probably think that scientists know everything about the common and essential vitamin B12, the only vitamin synthesized by soil microbes. In fact, one part of this biosynthesis has puzzled researchers for at least 50 years. But now, MIT and Harvard biologists have solved this vitamin puzzle by discovering that a single enzyme known as BluB synthesizes the vitamin. So what is the next challenge for the researchers? It's to discover why the soil microorganisms synthesize the vitamin B12 at all, because neither them — nor the plants they're attached to — need it to live.

This work "completes a piece of our understanding of a process very fundamental to life," said Graham Walker, MIT professor of biology, who led the research about the catalyzing effects of the BluB enzyme.

The Mystery of Vitamin B12 Finally Solved
"BluB catalyzes the formation of the B12 fragment known as DMB [dimethylbenzimidazole for the curious], which joins with another fragment, produced by a separate pathway, to form the vitamin. One of several possible reasons why it took so long to identify BluB is that some bacteria lacking the enzyme can form DMB through an alternate pathway", Walker said.

Above is a "cross-section of BluB's molecular surface. The two-fold axis lies along the y axis such that the si-face of FMN is viewed on the left and re-face on the right. The surface is coloured according to electrostatic potential, where blue is electropositive, red is electronegative and kB is Boltzmann's constant". (Credit: Graham Walker laboratory, via Nature) Here are two links to a larger version of this picture and to other figures and tables.


It's really interesting to note that the vitamin B12 biosynthesis involves the unusual "cannibalization" of vitamin B2.

"One of the most unusual aspects of BluB-catalyzed synthesis is its cannibalization of a cofactor derived from another vitamin, B2. During the reaction, the B2 cofactor is split into more than two fragments, one of which becomes DMB. Normally, the B2-derived cofactor would assist in a reaction by temporarily holding electrons and then giving them away. Such cofactors are not consumed in the reaction. Cannibalization of a cofactor has very rarely been observed before in vitamin synthesis or any type of biosynthetic pathway", says Michiko Taga, an MIT postdoctoral fellow in Walker's lab.

This work has been reported by Nature under the name "BluB cannibalizes flavin to form the lower ligand of vitamin B12" (Volume 446, Number 7134, Pages 449-453, March 22, 2007). Here are two links to the abstract and to the editor's summary, "The long road to vitamin B12".

So now that the biologists know how the vitamin B12 is synthesized, what will be their next research step? "Still to be explored is the question of why soil bacteria synthesize B12 at all, Walker said. Soil microorganisms don't require B12 to survive, and the plants they attach themselves to don't need it either, so he speculates that synthesizing B12 may enable the bacteria to withstand 'challenges' made by the plants during the formation of the symbiotic relationship".


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4 Vitamins to Have a Better Sex Life

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4 Vitamins to Have a Better Sex LifeMost people know that a good sex life has endless physical and psychological health benefits, including a stronger immune system, better breathing and circulation and healthier skin. A good sex life can also relieve chronic pain and reduce symptoms of depression and anxiety. But did you know that better nutrition can help you have that good sex life? Read on for an overview about some vitamins that can help you lead a better sex life as well as increase your overall health. Keep in mind that as much as possible, your vitamin supply should come from the food and drink you consume, rather than vitamin supplements.

1. Vitamin A: Vitamin A is essential for normal reproduction, and a deficiency of Vitamin A has been shown to cause atrophy of the testicles and ovaries in male and female rats, leading to sterlization. A deficiency in vitamin A is also thought to result in a decreased production of sex hormones as well as dry, scaly skin (it is needed for soft and beautiful skin). Some good sources of vitamin A are fish, eggs, cheese, yogurt, green leafy vegetables and yellow fruit.

2. Vitamin B-1: Vitamin B-1 is essential to energy production and the metobolism of carbohydrates, proteins and fats, so a deficiency of vitamin B-1 can lead to decreased energy and reduced sex drive. More symptoms of deficiency include fatigue, decreased alertness, constipation and heart symptoms (like rapid heartbeat). Some good sources of vitamin B-1 are nuts, asparagus, beans, pineapple, whole wheat, brown rice and other whole grains.

3. Vitamin B-3: Deficiency of vitamin B-3, also called niacin, can lead to skin eruptions, bowel problems and even mental problems. Sex life is impacted by the presence of vitamin B-3 because it increases blood flow to the extremities, including the brain. Problems with the nerve and digestive systems caused by vitamin B-3 deficiency can negatively affect your sex life. Some good sources of vitamin B-3 are lean meat, chicken, fish, broccoli and yogurt.

4. Vitamin C: Vitamin C influences a good sex life with its role in the absorption of iron, the formation of blood cells and the metabolism of the adrenal gland, all processes that affect your sex life. Iron helps oxygenation of the tissues for energy production, while blood carries oxygen, hormones and nutrients to the organs, glands and tissues. The adrenal gland produces lots of hormones that influence your sex life, including a hormone that helps to stimulate orgasm. In addition, vitamin C also strengthens your immune system, protects against stress and helps keep your joints limber and active. Can you see all the potential benefits from vitamin C? Good sources of vitamin C include strawberries, tomatoes and other citrus fruits, like oranges.

Several other vitamins, including vitamin D, vitamin E and folic acid, have direct and indirect effects on a good sex life and good health in general. The next step is to plan meals accordingly so that you naturally consume enough of these vitamins to reap the benefits they have to offer. Keep in mind that consumption of these vitamins for a better sex life and better health should be a lifelong priority, rather than a short-term nutrition or weight loss goal.

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